Protein & Peptide Letters

Prof. Ben M. Dunn  
Department of Biochemistry and Molecular Biology
University of Florida
College of Medicine
P.O. Box 100245
Gainesville, FL


Ubiquitin Carboxyl Hydrolase L1 Significance for Human Diseases

Author(s): Dang Ngoc Anh Suong, Dang Thi Phuong Thao, Yamaguchi Masamitsu and Tran Linh Thuoc

Affiliation: Department of Molecular and Environmental Biotechnology, University of Science, Vietnam National University in Ho Chi Minh City, Vietnam; Department of Applied Biology, Insect Biomedical Research Center, Kyoto Institute of Technology, Matsugasaki, Sakyo-ku, Kyoto 606-8585, Japan.


Ubiquitin carboxyl hydrolase L1 (UCH-L1) is an abundant multifunctional neuron protein. It plays an important role in maintaining the ubiquitin proteasome system (UPS), vital for recognizing and degrading dysfunctional proteins in organisms. In recent decades, UCH-L1 has been implicated in the pathogenesis of many diseases, including neurodegenerative disorders, cancer and diabetes. However, the mechanisms of UCH-L1 involvement have yet to be revealed in detail. Since UCH-L1 contributes many different functions to cell metabolism, its role and regulation might be more complex than previously thought and it has become a research target in many laboratories. In this review, we summarize recent findings related to the actions of UCH-L1 in several human diseases.

Keywords: Cancer, diabetes type-2, Parkinson’s disease, ubiquitination, UCH-L1, Ubiquitin proteasome system.

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Article Details

Page: [624 - 630]
Pages: 7
DOI: 10.2174/0929866521666140403125959