Ubiquitin Carboxyl Hydrolase L1 Significance for Human Diseases
Dang Ngoc Anh Suong, Dang Thi Phuong Thao, Yamaguchi Masamitsu and Tran Linh Thuoc
Affiliation: Department of Molecular and Environmental Biotechnology, University of Science, Vietnam National University in Ho Chi Minh City, Vietnam; Department of Applied Biology, Insect Biomedical Research Center, Kyoto Institute of Technology, Matsugasaki, Sakyo-ku, Kyoto 606-8585, Japan.
Ubiquitin carboxyl hydrolase L1 (UCH-L1) is an abundant multifunctional neuron protein. It plays an important
role in maintaining the ubiquitin proteasome system (UPS), vital for recognizing and degrading dysfunctional proteins
in organisms. In recent decades, UCH-L1 has been implicated in the pathogenesis of many diseases, including neurodegenerative
disorders, cancer and diabetes. However, the mechanisms of UCH-L1 involvement have yet to be revealed in
detail. Since UCH-L1 contributes many different functions to cell metabolism, its role and regulation might be more complex
than previously thought and it has become a research target in many laboratories. In this review, we summarize recent
findings related to the actions of UCH-L1 in several human diseases.
Keywords: Cancer, diabetes type-2, Parkinson’s disease, ubiquitination, UCH-L1, Ubiquitin proteasome system.
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