Synthesis and Anticancer Activity of Some 2-[3/4-(2-Substituted Phenyl-2- oxoethoxy)benzylidene]-6-substituted-2,3-dihydro-1H-inden-1-one Derivatives
Nalan Gundogdu-Karaburun, Ahmet Cagri Karaburun, Seref Demirayak, Ismail Kayagil and Leyla Yurttas
Affiliation: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, 26470 Eskisehir, Turkey.
The synthesis of 2-[3/4-(2-substituted phenyl-2-oxoethoxy)benzylidene]-6-substituted-2,3-dihydro-1H-inden-1-
one derivatives and the investigation of their anticancer activity were studied. 2-(3- or 4-Hydroxybenzylidene)-6-
substituted-2,3-dihydro-1H-inden-1-ones were reacted with suitable 2-bromoacetophenones to give 2-[3/4-(2-substituted
phenyl-2-oxoethoxy)benzylidene]-6-substituted-2,3-dihydro-1H-inden-1-one derivatives. The structure elucidation of the
synthesised compounds was performed by IR, 1H-NMR, mass spectroscopic data and elemental analyses. The anticancer
screening was carried out in National Cancer Institute (NCI), USA. Notable activity was obtained for some compounds.
Keywords: 2, 3-Dihydro-1H-inden-1-one, Aurone analogue, Anticancer activity.
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