Surface-enhanced Raman spectroscopy (SERS) is rapidly emerging as a powerful analytical tool for trace
analysis of metallic substrates. While innovative numerical applications of SERS have been developed, it is still a challenge
to fabricate cost-effective and reproducible metallic substrates for SERS probes. Laser processing, especially using
ultrafast pulsed laser, can address this issue owing to their high quality processing. Herein, we investigate critical technical
requirements and the latest advancements in laser-processing substrates for SERS, while highlighting several diverse
applications. In light of its powerful enhancement of Raman scattering, SERS will remain an exciting research area for
highly sensitive, resolved analysis into the foreseeable future.
Keywords: Enhancement factor, laser interference, laser processing, metal nanostructure, Raman scattering, surface enhancement.
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