Current Microwave Chemistry

Bimal K. Banik
Vice President of Research & Education Development
Community Health Systems of South Texas (CHSST)
Edinburg, TX


Microwave Assisted Synthesis of ethyl-quinolon-4-one-3-carboxylates and Hydrolysis to quinolon-4-one-3-carboxylic Acids

Author(s): Ivana Malvacio, D. Mariano. A. Vera and Elizabeth L. Moyano

Affiliation: INFIQC - Organic Chemistry Department, School of Chemical Sciences, National University of Cordoba, Cordoba, CP 5000, Argentine.

Keywords: Carboxylic acids, catalysis, cyclization, hydrolysis, malonates, microwave, open-vessel, quinolones, sealed-vessel, thermolysis.

Graphical Abstract:


A fast and efficient microwave assisted synthesis of several ethyl-quinolon-4-one-3-carboxylates and quinolon- 4-one-3-carboxylic acids has been developed. The 3-carboethoxy quinolones are easily obtained in a one-pot procedure through the cyclization of aminomethylenemalonate intermediates obtained by reaction of different p-substituted anilines and diethyl-ethoxymethylenmalonate. These quinolones are then irradiated under base hydrolysis conditions to get the carboxylic acids through a very fast and clean approach.

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Article Details

Page: [52 - 58]
Pages: 7
DOI: 10.2174/2213335601666140402002204