Microwave Assisted Synthesis of ethyl-quinolon-4-one-3-carboxylates and Hydrolysis to quinolon-4-one-3-carboxylic Acids
Ivana Malvacio, D. Mariano. A. Vera and Elizabeth L. Moyano
Affiliation: INFIQC - Organic Chemistry Department, School of Chemical Sciences, National University of Cordoba, Cordoba, CP 5000, Argentine.
Keywords: Carboxylic acids, catalysis, cyclization, hydrolysis, malonates, microwave, open-vessel, quinolones, sealed-vessel,
A fast and efficient microwave assisted synthesis of several ethyl-quinolon-4-one-3-carboxylates and quinolon-
4-one-3-carboxylic acids has been developed. The 3-carboethoxy quinolones are easily obtained in a one-pot procedure
through the cyclization of aminomethylenemalonate intermediates obtained by reaction of different p-substituted anilines
and diethyl-ethoxymethylenmalonate. These quinolones are then irradiated under base hydrolysis conditions to get the
carboxylic acids through a very fast and clean approach.
Rights & PermissionsPrintExport