Microwave Assisted Synthesis of ethyl-quinolon-4-one-3-carboxylates and Hydrolysis to quinolon-4-one-3-carboxylic Acids

Title:Microwave Assisted Synthesis of ethyl-quinolon-4-one-3-carboxylates and Hydrolysis to quinolon-4-one-3-carboxylic Acids

Volume: 1 Issue: 1

Author(s): Ivana Malvacio, D. Mariano. A. Vera and Elizabeth L. Moyano

Affiliation:

Keywords: Carboxylic acids, catalysis, cyclization, hydrolysis, malonates, microwave, open-vessel, quinolones, sealed-vessel, thermolysis.

Abstract: A fast and efficient microwave assisted synthesis of several ethyl-quinolon-4-one-3-carboxylates and quinolon- 4-one-3-carboxylic acids has been developed. The 3-carboethoxy quinolones are easily obtained in a one-pot procedure through the cyclization of aminomethylenemalonate intermediates obtained by reaction of different p-substituted anilines and diethyl-ethoxymethylenmalonate. These quinolones are then irradiated under base hydrolysis conditions to get the carboxylic acids through a very fast and clean approach.

Cite this article as:

Malvacio Ivana, Vera Mariano. A. D. and Moyano L. Elizabeth, Microwave Assisted Synthesis of ethyl-quinolon-4-one-3-carboxylates and Hydrolysis to quinolon-4-one-3-carboxylic Acids, Current Microwave Chemistry 2014; 1 (1) . https://dx.doi.org/10.2174/2213335601666140402002204