Aqua Mediated One-Pot Synthesis of 2-Amino-tetrahydrobenzo[b]pyran Derivatives Catalyzed by Mg(NO3)2•6H2O

Author(s): Boudjemaa Boumoud, Amina Debbache, Taoues Boumoud, Raouf Boulcina, Abdelmadjid Debache.

Journal Name: Letters in Organic Chemistry

Volume 11 , Issue 7 , 2014

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Graphical Abstract:


We describe herein a clean and efficient one-pot synthesis of 4H-benzo[b]pyran derivatives using dimedone, active methylene nitriles and aryl aldehyde via Knoevenagel condensation followed by Michael addition in the presence of Mg(NO3)2•6H2O as catalyst and water as a green solvent. The advantages of this method lie in its simplicity, low catalyst loading, cost effectiveness and easy handling. The present method also allows us to synthesize highly functionalized tetrahydrobenzo[b]pyran derivatives from simple and readily available starting materials.

Keywords: Mg(NO3)2•6H2O, multi-component reaction, 4H-benzo[b]pyran, active methylene nitrile, aqua mediated, dimedone.

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Article Details

Year: 2014
Page: [475 - 479]
Pages: 5
DOI: 10.2174/1570178611666140401221534
Price: $58

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