Aqua Mediated One-Pot Synthesis of 2-Amino-tetrahydrobenzo[b]pyran Derivatives Catalyzed by Mg(NO3)2•6H2O
Boudjemaa Boumoud, Amina Debbache, Taoues Boumoud, Raouf Boulcina and Abdelmadjid Debache
Affiliation: Laboratoire de Synthese de Molecules d' Interets Biologiques, Departement de Chimie, Faculte des Sciences Exactes, Universite Constantine 1, 25000 Constantine, Algerie.
Keywords: Mg(NO3)2•6H2O, multi-component reaction, 4H-benzo[b]pyran, active methylene nitrile, aqua mediated, dimedone.
We describe herein a clean and efficient one-pot synthesis of 4H-benzo[b]pyran derivatives using dimedone,
active methylene nitriles and aryl aldehyde via Knoevenagel condensation followed by Michael addition in the presence
of Mg(NO3)2•6H2O as catalyst and water as a green solvent. The advantages of this method lie in its simplicity, low catalyst
loading, cost effectiveness and easy handling. The present method also allows us to synthesize highly functionalized
tetrahydrobenzo[b]pyran derivatives from simple and readily available starting materials.
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