Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
USA
Email: lddd@benthamscience.org

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4'-Modified Pyrimidine Nucleosides as Potential Anti-hepatitis C Virus (HCV) Agents

Author(s): Neeraj Shakya, Satish Vedi, Chao Liang, Babita Agrawal, Rakesh Kumar.

Graphical Abstract:


Abstract:

Herein, we have investigated novel pyrimidine nucleosides bearing a 4’-carboxyl functionality (6-10, 13 and 15) as anti-HCV agents. In this new class of compounds, 7, 9, 10 and 15 demonstrated in vitro anti-HCV activity similar to or better than a known anti-HCV drug, ribavirin. In this work, we also, surprisingly, identified a 3’-sulfoxide analog of 3’-thiacytidine (16), obtained as a side product during the synthesis of 15, as a potent inhibitor of HCV replication at the concentration similar to that of ribavirin. No detectable in vitro cytotoxicity was observed for the investigated compounds up to the highest concentration tested.

Keywords: Hepatitis C virus, Anti-HCV effect, Synthesis, Nucleosides.

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Article Details

VOLUME: 11
ISSUE: 7
Year: 2014
Page: [917 - 921]
Pages: 5
DOI: 10.2174/1570180811666140401184856
Price: $58