4'-Modified Pyrimidine Nucleosides as Potential Anti-hepatitis C Virus (HCV) Agents
Herein, we have investigated novel pyrimidine nucleosides bearing a 4’-carboxyl functionality (6-10, 13 and
15) as anti-HCV agents. In this new class of compounds, 7, 9, 10 and 15 demonstrated in vitro anti-HCV activity similar
to or better than a known anti-HCV drug, ribavirin. In this work, we also, surprisingly, identified a 3’-sulfoxide analog of
3’-thiacytidine (16), obtained as a side product during the synthesis of 15, as a potent inhibitor of HCV replication at the
concentration similar to that of ribavirin. No detectable in vitro cytotoxicity was observed for the investigated compounds
up to the highest concentration tested.
Keywords: Hepatitis C virus, Anti-HCV effect, Synthesis, Nucleosides.
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