Towards a Poly-Functional Synthetic-Antimalarial Vaccine: Incorporating Non-Natural Elements into Artificially-Made Peptides for Mimicking Functional Pathogen Ligand Structures Representing New Site-Directed Vaccine Components

Author(s): Jose Manuel Lozano, Manuel Elkin Patarroyo.

Journal Name:Current Immunology Reviews

Volume 9 , Issue 4 , 2013

Abstract:

The molecular basis for obtaining novel anti-malarial vaccine candidates depends on a considered selection of antigenic peptides, mainly derived from Plasmodium antigens’ non-polymorphic regions. Since such targeted-molecules are poorly immunogenic when tested as vaccine components, they usually have to be modified to overcome their immunological phenotype. Transition state theory, explaining how peptidases catalyse a given peptide bond breakage, thus led to reduced amide pseudopeptides being proposed as possible mimetics for a transition-state. Stabilising such high-energy molecular stages could become a strategy for inducing antibodies potentially harbouring catalytic properties. Hence, isostere-bond peptido-mimetics represented a rational choice as potential abzyme-inducers and site-directed designed reduced amide pseudopeptides for obtaining peptide-analogues from selected malarial high-binding motifs. This novel family of vaccine candidates has proved to be an efficient functional antibody-inducer, the latter acting as efficient blockers of Plasmodium infection of human and mouse RBCs.

Keywords: Antimalarial vaccine, catalytic antibody, passive immunisation, peptide-bond isostere, peptido-mimetic, pseudopeptide.

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Article Details

VOLUME: 9
ISSUE: 4
Year: 2013
Page: [261 - 275]
Pages: 15
DOI: 10.2174/1573395510666140401180738
Price: $58