Expanding the Therapeutic Potential of Statins by Means of Nanotechnology Enabled Drug Delivery Systems

Author(s): Bilquis Romana , Mellissa Batger , Clive A. Prestidge , Gaia Colombo , Fabio Sonvico .

Journal Name: Current Topics in Medicinal Chemistry

Volume 14 , Issue 9 , 2014

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Abstract:

Statins are effective lipid lowering agents traditionally used for the primary and secondary prevention of cardiovascular disease. Statins also exert a range of pleiotropic effects that make them attractive candidates for use in a wide range of disorders, in particular inflammatory and immune mediated conditions. However, the exploitation of such pleiotropic effects has been greatly hindered by poor bioavailability and adverse effects on muscles and the liver at higher doses. Nanotechnology is often suggested as the solution to this problem, as it enables an increased bioavailability of statins. Moreover, colloidal carriers can offer targeted drug delivery approaches that enable localised biological effects of statins, further reducing their potential for unwanted toxicity and adverse effects. This article reviews the available evidences for the increased potential of statin therapy when administered in nano-formulations such as nanocrystals, nanoparticles, liposomes, micelles and various nano-enabled devices.

Keywords: Liposomes, micelles, nanocapsules, nanocrystals, nanoparticles, nanospheres, pleiotropic effects, statins.

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Article Details

VOLUME: 14
ISSUE: 9
Year: 2014
Page: [1182 - 1193]
Pages: 12
DOI: 10.2174/1568026614666140329232252
Price: $58

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