PEGylated Polyester-Based Nanoncologicals
Claudia Conte, Ivana d’Angelo, Agnese Miro, Francesca Ungaro and Fabiana Quaglia
Affiliation: Department of Pharmacy, University of Napoli Federico II, Via D. Montesano 49, 80131 Napoli – Italy.
Keywords: Cancer, chemotherapeutics, drug targeting, nanoparticles, nanotechnology, polyethylenglycol, polymers.
Several PEGylated polyester-based nanoncologicals have been proposed in the literature, some of them nowadays
being under preclinical/clinical trials or marketed. In this review, we describe the main features of PEGylated polyesters
and their correspondent nanocarriers. A first part is devoted to intravenously injectable PEGylated nanocarriers,
which represent the systems most investigated so far. After describing fundamental design rules dictated by the administration
route, PEGylated nanocarriers currently under preclinical/clinical investigation or in the market will be described
from a technological point of view and related therapeutic implications discussed. Finally, new perspective of use of PEGylated
nanocarriers for oral and pulmonary delivery of anticancer drugs will be considered.
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