An Update on the Cardiovascular Effects of Quercetin, a Plant Flavonoid
Mohammed A. Islam, Robert W. Schmidt, Simi Gunaseelan and Anthony Sanchez
Affiliation: West Coast University School of Pharmacy, 590 N. Vermont Ave, Los Angeles, CA-90004, USA.
Quercetin, a widely occurring plant flavonoid, is well-known for its antioxidant activity. A great deal of research
in the form of animal and cell culture studies has been performed over the last 30 years, as well as a few clinical
studies in human populations; however, its specific effects on various contributing factors to cardiovascular disease are
not fully understood. This review seeks to summarize many of the latest studies regarding the effects of quercetin on cardiovascular
health. Overall, the research reflects positive effects of quercetin on atherosclerosis, hypertension, dyslipidemia
and endothelial function. However, in vivo studies have shown that quercetin imparts varying plasma levels due to its
poor aqueous solubility and low stability in biological fluids. Research efforts are currently being devoted to overcome
these limitations by designing and testing modified forms of quercetin or improved formulations which provide enhanced
bioavailability and higher efficacy. The development of improved dosage forms for in vivo administration of quercetin
and well-designed clinical studies are warranted for further evaluation of the effects of quercetin on cardiovascular health.
Keywords: Antioxidants, atherosclerosis, cardiovascular disease, dyslipidemia, endothelial function, oxidative stress, plant
flavonoid, quercetin, formulations.
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