Helicobacter pylori: An Overview on Antimicrobials and Drug Delivery Systems for its Eradication
Sally A. El-Zahaby, Abeer A. Kassem and Amal H. El-Kamel
Affiliation: Department of Pharmaceutics, Pharos University in Alexandria, Canal El- Mahmoudia Street, Smouha. Alexandria, Egypt, P.O. Box 37, Sidi Gaber, Alexandria 21311, Egypt.
Since the discovery of Helicobacter pylori (H. pylori) in the early 1980s, its eradication has been one of the
most important global challenges in gastroenterology. Various circumstances make the treatment with antimicrobials particularly
difficult. One problem has been that antibiotics commonly used were designed for the treatment of infections
throughout the body rather than for delivering high concentrations locally within the stomach. Many gastroretentive dosage
forms were developed in order to eradicate the infection, yet additional advancements are still needed to eliminate the
infection completely and decrease its prevalence worldwide. An overview on different antimicrobials and a literature survey
about different drug delivery systems used in eradication of H. pylori infection are presented in this review.
Keywords: Gastroretentive, Helicobacter pylori, Mucopenetration, Specific targeting.
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