Apolipoprotein E Gene Variants of Alzheimer's Disease and Vascular Dementia Patients in a Community Population of Nanking
Wen-Zheng Chu, Li Gong, Ying-Qiu Xu, Guo-Hua Cai and Kuo-Chen Chou
Affiliation: First Affiliated Hospital with Nanking Medical University, Nanking, Jiangsu Province, 210036 China.
Keywords: Alzheimer’s disease, vascular dementia, apolipoprotein E.
To explore apolipoprotein E gene variants distribution among the patients of Alzheimer’s disease and vascular
dementia for the elderly community population in Nanking, the polymerase chain reaction and restriction fragment length
polymorphism techniques were employed to analyze the gene frequency of apolipoprotein E (ApoE) for 113 cases with
Alzheimer’s disease (AD), 85 cases with vascular dementia (VaD), 147 cases with questionable dementia (QD), and 396
dementia-free controls. It was found that ApoE ε4 gene container (37.17%) and allele frequency (21.24±2.72) of ApoE ε4
in AD group were significantly higher than those in both control and VaD group (p<0.05). With the increment of ε4 gene
dose, the incidence of the AD was significantly increased. Compared with the control group, ApoE ε4 had risk ratio (RR)
of 1.82 to develop AD (p =4e-4), and attributable risk percentage (ARP) of 45%. These results suggest that ApoE ε4 gene
may be responsible for up to 45% of the genetic component of Alzheimer’s disease, and may act as a discriminator between
AD and VaD as well.
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