Substance P at the Neuro-Immune Crosstalk in the Modulation of Inflammation, Asthma and Antimicrobial Host Defense
Jia Sun and Madhav Bhatia
Affiliation: (Jia Sun) at the Synergetic Innovation Center of Food Safety and Nutrition, State Key Laboratory of Food Science and Technology, and School of Food Science and Technology, Jiangnan University, Wuxi 214122, P.R. China.
Substance P, a neuropeptide belonging to the tachykinin family is a pleiotropic peptide with specific neural
activities and involved in immunomodulation and antimicrobial host defense. It has been found to modulate a variety of
inflammatory processes, including acute pancreatitis, sepsis, systemic inflammatory response syndrome and asthma. Also
notably, substance P shares common bio-physical and -chemical properties such as low molecular mass, cathionicity and
amphipathicity with antimicrobial peptides. It is therefore suggested to take part in host defense at specialized locations.
The review aims to highlight undated understanding on substance P in inflammation, allergy and its antimicrobial
activities with potential implications in infection and host defense.
Therapeutic implications of the peptide, modulators of peptide expression and receptor signalling will be highlighted in
each topic. Taken together, these topics will be of significant values for future pharmaceutical investigation and
application of the field.
Keywords: Antimicrobial peptides, cathelicidins, immunomodulation, substance P.
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