The Biomolecular Screening Facility (BSF) is a multidisciplinary laboratory created in
2006 at the Ecole Polytechnique Federale de Lausanne (EPFL) to perform medium and high
throughput screening in life sciences-related projects. The BSF was conceived and developed to
meet the needs of a wide range of researchers, without privileging a particular biological discipline
or therapeutic area. The facility has the necessary infrastructure, multidisciplinary expertise and
flexibility to perform large screening programs using small interfering RNAs (siRNAs) and
chemical collections in the areas of chemical biology, systems biology and drug discovery. In the
framework of the National Centres of Competence in Research (NCCR) Chemical Biology, the
BSF is hosting ‘ACCESS’, the Academic Chemical Screening Platform of Switzerland that provides
the scientific community with chemical diversity, screening facilities and know-how in chemical
genetics. In addition, the BSF started its own applied research axes that are driven by innovation in
thematic areas related to preclinical drug discovery and discovery of bioactive probes.
Keywords: Academic screening, assay automation, assay development, high-content screening, hits prioritization, hits-toleads,
phenoytpic assays, target-based assays.
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