Combinatorial Chemistry & High Throughput Screening

Rathnam Chaguturu 
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UCLA’s Molecular Screening Shared Resource: Enhancing Small Molecule Discovery with Functional Genomics and New Technology

Author(s): Robert Damoiseaux

Affiliation: Molecular Shared Screening Resource, UCLA, California NanoSystems Institute, 570 Westwood Plaza, Room 2145, Los Angeles, CA 90095, USA.

Keywords: Academic drug discovery, high throughput screening, functional genomics, nanomaterials, new technology, RNAi, shRNA, small molecules.

Abstract:

The Molecular Screening Shared Resource (MSSR) offers a comprehensive range of leading-edge high throughput screening (HTS) services including drug discovery, chemical and functional genomics, and novel methods for nano and environmental toxicology. The MSSR is an open access environment with investigators from UCLA as well as from the entire globe. Industrial clients are equally welcome as are non-profit entities. The MSSR is a fee-for-service entity and does not retain intellectual property. In conjunction with the Center for Environmental Implications of Nanotechnology, the MSSR is unique in its dedicated and ongoing efforts towards high throughput toxicity testing of nanomaterials. In addition, the MSSR engages in technology development eliminating bottlenecks from the HTS workflow and enabling novel assays and readouts currently not available.

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Article Details

VOLUME: 17
ISSUE: 4
Page: [356 - 368]
Pages: 13
DOI: 10.2174/1386207317666140323134621