Functional Genomics Down Under: RNAi Screening in the Victorian Centre for Functional Genomics
Daniel W. Thomas, Cathryn M. Gould, Yanny Handoko and Kaylene J. Simpson
Affiliation: Victorian Centre for Functional Genomics, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia.
Keywords: RNAi, functional genomics, high throughput screening, high content imaging.
The Victorian Centre for Functional Genomics (VCFG) is an RNAi screening facility
housed at the Peter MacCallum Cancer Centre in Melbourne, Australia. The Peter Mac is
Australia’s largest dedicated Cancer Research Institute, home to a team of over 520 scientists that
focus on understanding the genetic risk of cancer, the molecular events regulating cancer growth
and dissemination and improving detection through new diagnostic tools (www.petermac.org).
Peter Mac is a well recognised technology leader and established the VCFG with a view to
enabling researchers Australia and New Zealand-wide access to cutting edge functional genomics
technology, infrastructure and expertise. This review documents the technology platforms
operated within the VCFG and provides insight into the workflows and analysis pipelines
currently in operation.
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