In the past decade, academic screening centers have been created in many universities
worldwide. Most of these screening centers are organized as core facilities that accept projects from
both within their organization and from external users in order to maximize staff and instrument
usage. The Max Planck Institute of Molecular Cell Biology and Genetics in Dresden, Germany, also
created such a screening facility named the Technology Development Studio (TDS). The mission of
the facility is to provide cell based screening services focused on high resolution confocal imaging.
The acquisition of high resolution images allows the mathematical description of cells with image
analysis to a high degree of precision. This precision in turn allows classifying phenotypes
accurately and compare different cellular treatments to discover underlying mechanisms.
Keywords: Chemical screening, complex biology, high content screening, multi parametric statistics, RNAi.
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