Combinatorial Chemistry & High Throughput Screening

Rathnam Chaguturu 
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The Technology Development Studio of the MPI-CBG: An Open Access Cell-Based Screening Facility

Author(s): Marc Bickle

Affiliation: Technology Development Studio, Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, D-01307, Dresden, Germany.


In the past decade, academic screening centers have been created in many universities worldwide. Most of these screening centers are organized as core facilities that accept projects from both within their organization and from external users in order to maximize staff and instrument usage. The Max Planck Institute of Molecular Cell Biology and Genetics in Dresden, Germany, also created such a screening facility named the Technology Development Studio (TDS). The mission of the facility is to provide cell based screening services focused on high resolution confocal imaging. The acquisition of high resolution images allows the mathematical description of cells with image analysis to a high degree of precision. This precision in turn allows classifying phenotypes accurately and compare different cellular treatments to discover underlying mechanisms.

Keywords: Chemical screening, complex biology, high content screening, multi parametric statistics, RNAi.

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Article Details

Page: [322 - 327]
Pages: 6
DOI: 10.2174/1386207317666140323133018