Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
USA
Email: lddd@benthamscience.org

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Anionic Linear Globular Dendrimer-G2-Ciprofloxacin Nano-Conjugate: Novel Agent against Wilson Disease Cell Model

Author(s): Narges Karimi, Mohammad Reza Aghasadeghi, Parichehr Yaghmaei, Hadi Fathi Moghaddam, Nasser Nassiri-Koopaei, Hamid Moloudian, Saleh Najafi, Seyed Ataaollah Shandiz, Mehdi Shafiee Ardestani.

Graphical Abstract:


Abstract:

Inherited defect of the gene ATP7B causes malexcretion of copper in the bile and leads to several complications that need treatment to deplete it from organs. Current therapy of Wilson disease, D-penicillamine has very serious side effects and drug with optimum therapeutic effects and minimum side effects is of importance. In the present study ciprofloxacin was conjugated with an anionic globular dendrimer to lower the intracellular copper concentration. The results showed its efficacy and safety to certain levels. Based on the results, ciprofloxacin-anionic linear globular dendrimer conjugate can be a useful option to reduce intracellular copper concentration and an investigational therapeutic agent in Wilson disease.

Keywords: Copper, Dendrimer-ciprofloxacin nano-particle, Fluoroquinolone, Metal ions, Wilson disease.

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Article Details

VOLUME: 11
ISSUE: 7
Year: 2014
Page: [908 - 916]
Pages: 9
DOI: 10.2174/1570180811666140322001829
Price: $58