Electrocatalytic Determination of 6-Mercaptopurine Using Multiwall Carbon Nanotubes Paste Electrode in the Presence of Methyldopa
Ali Sharifian Isfahani, Mohsen Keyvanfard, Behzad Rezaei and Khadijeh Alizad
Affiliation: Department of Chemistry, Majlesi Branch, Islamic Azad University, Isfahan, Iran.
The main purpose of this study is to develop a sensitive and selective modified carbon-paste electrode (CPE)
with multiwall carbon nanotubes (MWCNTs) for the determination of 6-mercaptopurine (6-MP) in the presence of methyldopa
(MD) as a mediator. Electrochemical methods, such as cyclic voltammetry, double step chronoamperometry and
square wave voltammetry (SWV), used to study the characterization of the proposed modified electrode. The results show
that MD can catalyze the oxidation of 6-MP in aqueous solution. Also, the catalytic rate constant (k), and diffusion
coefficient (D) for 6-MP were estimated. The pick currents of 6-MP increased linearly with concentration in the ranges of
0.31–550 µmol L–1, with detection limit of 0.1 µmol L–1. The relative standard deviation (RSD %) for seven replicate
measurements of 0.7 µmol L–1 6-MP was 1.6%. The prepared electrode is successfully applied for the voltammetric determination
of 6-MP in pharmaceutical and biological samples.
Keywords: 6-Mercaptopurine determination, electrocatalysis, methyldopa, multiwall carbon nanotubes paste electrode,
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