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Current Organic Synthesis
ISSN (Print): 1570-1794
ISSN (Online): 1875-6271
Epub Full Text Article
DOI: 10.2174/1570179411666140321180629      Price:  $95









Antitubercular Natural Terpenoids: Recent Developments and Syntheses

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Author(s): Estibaliz Sansinenea and Aurelio Ortiz
Abstract:
Tuberculosis (TB), mainly caused by Mycobacterium tuberculosis, is the leading killer among all infectious diseases worldwide and is responsible for more than two million deaths annually. The recent increase in the number of multi-drug resistant clinical isolates of M. tuberculosis has created an urgent need for the discovery and development of new antituberculosis leads. This review covers recent reports terpenoids that have demonstrated moderate to high activity in bioassays realized in vitro against M. tuberculosis; their organic synthesis is included in some cases. In this review, monoterpenoids, diterpenoids, sesquiterpenes, sesterterpenes and triterpenes, their structural analogs and semisynthetic derivatives will be discussed, with particular emphasis on the reported syntheses for each compound.
Keywords:
Tuberculosis, antitubercular natural products, terpenoids, synthesis of natural terpenoids
Affiliation:
Facultad de Ciencias Químicas de la Benemérita Universidad Autónoma de Puebla, Puebla Pue., 72570, México.