Current Drug Metabolism

Michael Sinz
Bristol Myers Squibb
Wallingford, CT


Design and Applications of Bioprecursors: A Retrometabolic Approach

Author(s): Suneela Dhaneshwar, Astha Jain and Kunal Tewari

Affiliation: Department of Pharmaceutical Chemistry, Poona College of Pharmacy, Bharati Vidyapeeth Deemed University, Pune-411 038, Maharashtra, India.


Bioprecursor by definition is a type of prodrug that is designed to tackle pharmaceutical, pharmacokinetic or pharmacodynamic shortcomings of a drug that limit its clinical use. A retrometabolic approach is used to design bioprecursors which upon activation by either phase-I or phase-II metabolic enzymes result into an active metabolite. A bioprecursor differs from its active metabolite in many respects like physico-chemical, biological and toxicological aspects. Present review focuses on salient features of design and chemistry of bioprecursors and their active metabolites, activating metabolic enzymes/reactions, reported examples from literature and applications. We hope that this extensive compilation would open doors to bioprecursors and their active metabolites as very promising resources for the discovery of novel drugs possessing high efficacy with lower number and extent of adverse effects.

Keywords: Activation, active metabolite, bioprecursor, biotransformation, phase- I metabolism, phase-II metabolism, prodrug.

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Article Details

Page: [291 - 325]
Pages: 35
DOI: 10.2174/1389200215666140318101432
Price: $58