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Systems Medicine Approaches for the Definition of Complex Phenotypes in Chronic Diseases and Ageing. From Concept to Implementation and Policies

Author(s): Jean Bousquet, Christian Jorgensen, Michel Dauzat, Alfredo Cesario, Thierry Camuzat, Rodolphe Bourret, Nicolas Best, Josep M. Anto, Frederic Abecassis, Pierre Aubas, Antoine Avignon, Melanie Badin, Anna Bedbrook, Hubert Blain, Arnaud Bourdin, Jacques Bringer, William Camu, Guilhaume Cayla, David J. Costa, Philippe Courtet, Jean-Paul Cristol, Pascal Demoly, Jean-Emmanuel de la Coussaye, Pierre Fesler, Fares Gouzi, Jean-Christophe Gris, Bernard Guillot, Maurice Hayot, Claude Jeandel, Olivier Jonquet, Laurent Journot, Sylvain Lehmann, Gwenaelle Mathieu, Jacques Morel, Gregory Ninot, Jacques Pelissier, Marie-Christine Picot, Francoise Radier-Pontal, Jean-Marie Robine, Michel Rodier, Francois Roubille, Ariane Sultan, Anne Wojtusciszyn, Charles Auffray, Rudi Balling, Cristina Barbara, Anne Cambon-Thomsen, Niels H. Chavannes, Alexander Chuchalin, George Crooks, Antoni Dedeu, Leonardo M. Fabbri, Judith Garcia-Aymerich, Jawad Hajjam, Elisabete Melo Gomes, Susana Palkonen, Francois Piette, Christophe Pison, David Price, Boleslaw Samolinski, Holger J. Schunemann, Peter J. Sterk, Panayiotis Yiallouros, Josep Roca, Philippe Van de Perre, Jacques Mercier.


Chronic diseases are diseases of long duration and slow progression. Major NCDs (cardiovascular diseases, cancer, chronic respiratory diseases, diabetes, rheumatologic diseases and mental health) represent the predominant health problem of the Century. The prevention and control of NCDs are the priority of the World Health Organization 2008 Action Plan, the United Nations 2010 Resolution and the European Union 2010 Council. The novel trend for the management of NCDs is evolving towards integrative, holistic approaches. NCDs are intertwined with ageing. The European Innovation Partnership on Active and Healthy Ageing (EIP on AHA) has prioritised NCDs. To tackle them in their totality in order to reduce their burden and societal impact, it is proposed that NCDs should be considered as a single expression of disease with different risk factors and entities. An innovative integrated health system built around systems medicine and strategic partnerships is proposed to combat NCDs. It includes (i) understanding the social, economic, environmental, genetic determinants, as well as the molecular and cellular mechanisms underlying NCDs; (ii) primary care and practice-based interprofessional collaboration; (iii) carefully phenotyped patients; (iv) development of unbiased and accurate biomarkers for comorbidities, severity and follow up of patients; (v) socio-economic science; (vi) development of guidelines; (vii) training; and (viii) policy decisions. The results could be applicable to all countries and adapted to local needs, economy and health systems. This paper reviews the complexity of NCDs intertwined with ageing. It gives an overview of the problem and proposes two practical examples of systems medicine (MeDALL) applied to allergy and to NCD co-morbidities (MACVIA-LR, Reference Site of the European Innovation Partnership on Active and Healthy Ageing).

Keywords: Chronic disease, co-morbidities, health system, systems medicine, patient, active and healthy ageing, MeDALL, MACVIA-LR.

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Article Details

Page: [5928 - 5944]
Pages: 17
DOI: 10.2174/1381612820666140314115505
Price: $58