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Current Radiopharmaceuticals
ISSN (Print): 1874-4710
ISSN (Online): 1874-4729
Epub Full Text Article
DOI: 10.2174/1874471007666140314094323      Price:  $95









Current Role and Future Perspectives of Radioiodinated MIBG in the Evaluation of Dementia with Lewy Bodies

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Author(s): Giorgio Treglia, Luca Ceriani and Luca Giovanella
Abstract:
Dementia with Lewy bodies (DLB) is the second most common cause of degenerative dementia after Alzheimer’s disease (AD). To improve the diagnosis of DLB, the latest diagnostic criteria incorporate findings from neuroimaging studies including sympathetic innervation imaging with iodine-123-metaiodobenzylguanidine (MIBG). According to these criteria a decreased MIBG myocardial uptake is an important finding supporting a clinical diagnosis of DLB. In this review the state of art and future perspectives of sympathetic innervation imaging by using MIBG in the diagnosis of DLB are discussed
Keywords:
MIBG, metaiodobenzylguanidine, dementia with Lewy bodies, dementia, innervation imaging
Affiliation:
Department of Nuclear Medicine and PET/CT Center, Ente Ospedaliero Cantonale Street: via Ospedale, 12; zip code: 6500; city: Bellinzona; country: Switzerland