Synthesis and Biological Evaluation of Novel N' (4-aryloxybenzylidene)- 1H-Benzimidazole-2 Carbohydrazide Derivatives as Anti-Tubercular Agents
Afsar Ali Siddiki, Vinod Kumar Bairwa and Vikas N. Telvekar
Affiliation: Institute of Chemical Technology, Department of Pharmaceutical Sciences and Technology, Mumbai 400 019, India.
Keywords: Anti-tubercular, benzimidazole, carbohydrazide esters, triclosan, molecular hybridization.
A series of structurally novel, (E)-N'-(4-aryloxybenzylidene)-1H-benzimidazole-2-carbohydrazide derivatives
were synthesized by molecular hybridization technique. All these compounds were evaluated against Mycobacterium
tuberculosis H37Rv strains using Resazurin Microtiter assay (REMA) method. These compounds showed good
antituberculosis activity with minimum inhibitory concentration (MIC) value of the range of 1.5-25 µg/mL.
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