Synthesis of Pyrimidine Derivatives from Three-component Reaction of Malononitrile, Aldehydes and Thiourea/Urea in the Presence of High Surface Area and Nanosized MgO as a Highly Effective Heterogeneous Base Catalyst

Author(s): Zahra Hassani.

Journal Name:Letters in Organic Chemistry

Volume 11 , Issue 7 , 2014

Graphical Abstract:


The three-component reaction of malononitrile, aldehydes and thiourea/urea, is applied to the formation of pyrimidine derivatives. The reaction occurs at best in EtOH at reflux, in the presence of high surface area and nanosized MgO. This methodology is more convenient to compare with alternative ways because it needs shorter reaction times, allows straightforward product isolation, and provides higher yields.

Keywords: High surface area, nanosized MgO, Pyrimidine derivatives, Three-component reaction.

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Article Details

Year: 2014
Page: [546 - 549]
Pages: 4
DOI: 10.2174/1570178611666140313005406
Price: $58