Synthesis of Pyrimidine Derivatives from Three-component Reaction of Malononitrile, Aldehydes and Thiourea/Urea in the Presence of High Surface Area and Nanosized MgO as a Highly Effective Heterogeneous Base Catalyst
The three-component reaction of malononitrile, aldehydes and thiourea/urea, is applied to the formation of
pyrimidine derivatives. The reaction occurs at best in EtOH at reflux, in the presence of high surface area and nanosized
MgO. This methodology is more convenient to compare with alternative ways because it needs shorter reaction times, allows
straightforward product isolation, and provides higher yields.
Keywords: High surface area, nanosized MgO, Pyrimidine derivatives, Three-component reaction.
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