Longitudinal Molecular Imaging of Burn Wound Healing: Effect of Staphylococcus aureus, or Lack of Tumor Necrosis Factor (TNF) or Interleukin-6 (Il-6)
Victoria Hamrahi, Walter Jung, John Benjamin and Edward A. Carter
Affiliation: Massachusetts General Hospital, Pediatric Gastrointestinal Unit, 114 16th Street (114-3503), Charlestown, MA 02129-4004, USA.
Burn wounds become colonized with bacteria during the course of recovery. In addition, there are some burn
patients whose wounds do not heal for months. In the present study, we attempted to determine: 1. If seeding of a burn
wound with Staphylococcus aureus would affect wound healing: and 2. If knocking out IL-6 and TNF, two cytokines
commonly associated with burn injury, would alter burn wound healing. Using bioluminescent Staphylococcus aureus,
there appeared to be no difference in the rate of wound healing between the inoculated burn wounds and the uninoculated
burn wounds in the wild type mice. However, burn wounds on the Il-6 or TNF knockout mice did not heal as quickly as
the wild type (WT mice). These data support the hypothesis that Staphylococcus aureus that colonize the wound may not
alter burn wound healing. However, the present data suggest that Il-6 and TNF may play a role in burn wound healing.
Keywords: Burn, burn wound healing, Il-6, Staphylococcus aureus, TNF.
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