Detection of Cryptococcus neoformans Capsular Antigen in HIV-Infected Patients in the State of Para in the North of Brazil
Maurimelia M. da Costa, Lucimar di Paula Madeira, Rosimar N.M. Feitosa, Marluísa de Oliveira G. Ishak, Ricardo Ishak, Silvia H.M. da Silva and Antonio C.R. Vallinoto
Affiliation: Universidade Federal do Para, Instituto de Ciencias Biologicas, Laboratorio de Virologia, Rua Augusto Correa no. 1, 66.075-910, Belem, Para, Brazil.
Keywords: Cryptococcus neoformans, HIV-1/AIDS, latex agglutination test.
Cryptococcus neoformans is an important cause of morbidity in HIV-infected patients worldwide. In the
northern region of Brazil, the prevalence of this infection is poorly known due to a lack of systematic investigations. This
study aimed to determine the occurrence of cryptococcosis by detecting antigenaemia in HIV-infected patients in the State
of Pará, Brazil. A latex Cryptococcus antigen detection kit was used to test 418 serum samples from HIV-infected patients
seen at two Infectious Disease Specialized Units in the State of Pará. The C. neoformans antigenaemia prevalence was
2.6%, and titres reached 1:8. The cases occurred mainly in asymptomatic females, and 45% presented CD4+ T lymphocyte
counts of fewer than 200 cells/mm3. These results show the importance of early C. neoformans antigenaemia detection to
prevent fungal disease.
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