Current HIV Research

Charles Wood  
University of Nebraska
Lincoln, NE


Detection of Cryptococcus neoformans Capsular Antigen in HIV-Infected Patients in the State of Para in the North of Brazil

Author(s): Maurimelia M. da Costa, Lucimar di Paula Madeira, Rosimar N.M. Feitosa, Marluísa de Oliveira G. Ishak, Ricardo Ishak, Silvia H.M. da Silva, Antonio C.R. Vallinoto.


Cryptococcus neoformans is an important cause of morbidity in HIV-infected patients worldwide. In the northern region of Brazil, the prevalence of this infection is poorly known due to a lack of systematic investigations. This study aimed to determine the occurrence of cryptococcosis by detecting antigenaemia in HIV-infected patients in the State of Pará, Brazil. A latex Cryptococcus antigen detection kit was used to test 418 serum samples from HIV-infected patients seen at two Infectious Disease Specialized Units in the State of Pará. The C. neoformans antigenaemia prevalence was 2.6%, and titres reached 1:8. The cases occurred mainly in asymptomatic females, and 45% presented CD4+ T lymphocyte counts of fewer than 200 cells/mm3. These results show the importance of early C. neoformans antigenaemia detection to prevent fungal disease.

Keywords: Cryptococcus neoformans, HIV-1/AIDS, latex agglutination test.

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Article Details

Year: 2013
Page: [647 - 651]
Pages: 5
DOI: 10.2174/1570162X12666140311125420
Price: $58