Letters in Organic Chemistry

Miguel Yus  
Universidad de Alicante Apdo
Alicante
Spain

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A Convenient Synthesis of New 2-Cyanomethylthieno[3,2-e][1,2,4]- triazolo[1,5-c]pyrimidine Derivatives

Author(s): Dhiab Jabli, Khaireddine Dridi and Mohamed L. El Efrit

Affiliation: Laboratory of Organic Chemistry, Department of Chemistry, Faculty of Sciences, El Manar University, El Manar II, Tunis 1060, Tunisia and Department of Chemistry, College of Sciences and Arts, Qassim University, Al-Rass, 53, Kingdom of Saudi Arabia.

Keywords: 2-Aminothiophene-3-carbonitrile, iminoethers, iminithieopyrimidin-3-ylamine, cyanoacetic acid hydrazide, thienotriazolopyrimidine.

Graphical Abstract:


Abstract:

A new series of 2-cyanomethylthienotriazolopyrimidines has been synthesized in good yield through a facile method using substituted aminothiophene-3-carbonitrile as building block and cyanoacetic acid hydrazide as reagent in one framework. The structure of the synthesized compounds was established on the basis of their mass and spectral data.

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Article Details

VOLUME: 11
ISSUE: 6
Page: [403 - 408]
Pages: 6
DOI: 10.2174/1570178611666140311005612