Current View on the Mechanism of Action of Perifosine in Cancer

Author(s): Joachim Fensterle , Babette Aicher , Irene Seipelt , Michael Teifel , Juergen Engel .

Journal Name: Anti-Cancer Agents in Medicinal Chemistry

Volume 14 , Issue 4 , 2014

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Abstract:

Perifosine treatment exhibits a complex molecular response including the inhibition of Akt or the induction of apoptosis via clustering of death receptors in lipid rafts. However, the molecular response can vary between different tumor entities and the contribution of each target pathway to the activity of Perifosine might be distinct depending on the tumor entity or the agent combined with Perifosine.

In this review we discuss the current view on the mechanism of action of perifosine in cancer and the contribution of the molecular targets of Perifosine to its activity.

Keywords: APL miltefosine, cancer, perifosine.

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Article Details

VOLUME: 14
ISSUE: 4
Year: 2014
Page: [629 - 635]
Pages: 7
DOI: 10.2174/1871520614666140309225912
Price: $58

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