Post-Translational Modification of Transcription Factors: Mechanisms and Potential Therapeutic Interventions
Sonia L. Planey, Raj Kumar and John A. Arnott
Affiliation: Basic Sciences, The Commonwealth Medical College, 525 Pine Street, Scranton, PA 18509, USA.
Keywords: Drug development, gene regulation, post-translational modifications, transcription factors, .
Transcription factors (TFs) orchestrate multiple cellular processes through tight regulation via post-translational
modifications (PTMs). Thus, decoding the combinations of PTMs should provide critical layer of information that can be
integrated into highly specific cellular outputs to reveal a network of genes and their target-specific regulation. Protein
modifications play a decisive role in various drug responses and eventually in prognosis for many life-threatening
diseases, and recent studies demonstrate that TF-based drug designing must consider structural and functional changes
due to PTMs, yet we are just beginning to grasp this enormity and the impact on normal development and disease
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