Hyper-Coagulable Profile with Elevated Pro-Thrombotic Biomarkers and Increased Cerebro- and Cardio-Vascular Disease Risk Exist Among Healthy Dyslipidemic Women
Claudia N. Ferreira, Maria G. Carvalho, Helton J. Reis, Karina B. Gomes, Marinez O. Sousa and Andras Palotas
Affiliation: Asklepios-Med, H-6722 Szeged, Kossuth Lajos sgt. 23, Hungary.
Dyslipidemia is one of the pathognomonic elements of athero-genesis, as well as cerebro- and cardio-vascular
disease (CCVD). Hemostatic factors are also involved in athero-sclerosis and ischemic changes, however their
relationship with disrupted lipid homeostasis is not well characterized. The aim of this study was to determine the
coagulation state of dyslipidemic patients and to evaluate their association with CCVD risk factors. Biochemical and
hematological parameters, as well as neuro-psychiatric profile of 109 dyslipidemic subjects and 107 normo-lipidic healthy
volunteers were assessed. Serum bio-marker levels and cognitive performance generally did not differ in the groups, but
prothrombin fragment 1+2 (F1+2) and D-dimer concentrations were markedly higher among women. Hyper-coagulability
was not associated with dyslipidemia, but was correlated with the female gender, which might pose an increased thromboembolic
risk in asymptomatic women.
Keywords: Cerebro- and cardio-vascular disease (CCVD), D-dimer, dyslipidemia, prothrombin fragment 1+2 (F1+2), risk
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