HIV-1 Rev Multimerization: Mechanism and Insights

Author(s): Thomas Vercruysse, Dirk Daelemans.

Journal Name:Current HIV Research

Volume 11 , Issue 8 , 2013


To export intron-containing viral mRNAs that encode the structural components of new viral particles from the nucleus to the cytoplasm, HIV-1 uses the cellular CRM1 export pathway that is exploited by the viral Rev protein. Rev multimerizes on the Rev response element (RRE) present in the intron-containing RNA species to bridge these to the cellular export factor CRM1. As a result, this Rev-RRE complex is exported to the cytoplasm. This review provides a systematic overview of different aspects of the crucial function of Rev multimerization, such as co-operative Rev-Rev and Rev-RNA interactions, the biological function of Rev multimerization, the relevance of Rev multimerization in the absence of RRE and its potential as a therapeutic target.

Keywords: Co-operative interactions, HIV-1, multimerization, protein-protein interactions, protein-RNA interactions, Rev, RNA export, viral replication control.

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Article Details

Year: 2013
Page: [623 - 634]
Pages: 12
DOI: 10.2174/1570162X12666140307094603
Price: $58