Synthesis and Pharmacological Screening of Novel 1,3-Disubstituted 5-Pyrazolones as Anticonvulsant Agents
Basant Kumar Singh, Narsingh Sachan and Pooja Chawla
Affiliation: Faculty of Pharmacy, Babu Banarasi Das National Institute of Technology and Management, Lucknow- 226028, India.
Keywords: Anticonvulsant, convulsion, MES, pharmacophore, pyrazol-5-one.
Two series of novel 1-(4-substitutedbenzoyl)-3-((2-oxoimidazolin-1-yl)methyl)-1H-pyrazol-5(4H)-one, 1-
4,5-dihydro-1H-pyrazol-3-yl)methyl) thio urea and 1-((1-(4-substitutedbenzoyl)-5-oxo-4,5-dihydro-1H-pyrazol-3-
yl)methyl)-3-phenyl thiourea were synthesized and characterized by IR, mass, 1HNMR spectroscopic techniques. The
synthesized compounds were evaluated for anticonvulsant activity by using maximal electroshock seizure (MES) model.
Among the newly synthesized compounds, most of the compounds showed significant activity and 1C2 emerged as the
most active analogue.
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