Novel Insights Into the Role of MicroRNA in Lung Cancer Resistance to Treatment and Targeted Therapy
Zhaohui Gong, Jie Yang, Jingqiu Li, Lihua Yang, Yanping Le, Shaomin Wang and Hui-Kuan Lin
Affiliation: Institute of Biochemistry and Molecular Biology, Ningbo University School of Medicine, 818 Fenghua Road, Ningbo, ZJ 315211, China.
Keywords: Drug resistance, metabolism, microRNA, polymorphism, targeted therapy.
Lung cancer is one of the most common malignant tumors and is the leading cause of cancer mortality
worldwide. However, drug resistance induced by chemotherapeutants to lung cancer cells is the primary issue during the
chemotherapy of lung cancer. Many mechanisms such as the changes of drug metabolism related genes and signal
pathways are involved in chemoresistance. MicroRNAs (miRNAs) are a class of endogenetic, non-coding, short-chain and
small RNAs that regulate cell growth, apoptosis and signal transduction. There are growing numbers of evidence
suggesting that miRNA polymorphisms associate with drug metabolism and resistance. In addition, differentially
expressed miRNAs play critical roles in the prediction of the sensitivity to chemotherapeutic agents in lung cancer. The
recent progress demonstrates that regulation of specific miRNA expression will break novel paths for overcoming lung
cancer resistance and the personalized therapy. Together, in this review we have discussed the current understanding of
the role of miRNA on drug resistance, and the potential implications of miRNA in lung cancer targeted therapy.
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