A new piperazine-functionalized Fe3O4/SiO2 magnetite nanoparticle was synthesized through the surface
modification of magnetic iron oxide nanoparticles by piperazine. Iron oxide nanoparticles were synthesized by coprecipitation
method and the surface modification process was achieved by treating the nanoparticles with tetraethyl
orthosilicate (TEOS), chloropropyl trimethoxy silane (CPTS) and piperazine. The developed functionalized iron oxide
nanoparticle was evaluated as a reusable heterogeneous organobase catalyst for the synthesis of 4H-chromene derivatives
from multi-component condensation reaction of 2-naphthol, malononitrile and aldehydes under solvent-free conditions.
To receive morphological and structural information on the as-prepared catalyst, the samples were investigated by various
techniques such as FT-IR, TEM, XRD, vibrating sample magnetometry (VSM), TGA and elemental analyzer. Under
appropriate conditions, all reactions afforded the desired products in good to excellent yields. Moreover, this catalyst can
be easily recovered by using a magnetic field and directly reused for at least six runs without significant loss of its
Keywords: Heterogeneous organobases, magnetic nanoparticles, piperazine, 2-amino-4H-chromenes, solvent-free.
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