Letters in Organic Chemistry

Gwilherm Evano
Free University of Brussels
Brussels
Belgium

Back

Synthesis of Some New Chromeno[2,3-b]pyridine and [1,2,4]Triazolo[1,5- a]quinoline Nucleoside Analogues with Expected Biological Activity

Author(s): Amira A. Ghoneim, Ahmed F. El-Farargy.

Graphical Abstract:


Abstract:

Direct preparation of 2-amino-5,6,7,8-tetrahydro-4-(4-methoxyphenyl)-7,7-dimethyl-5-oxo-4H-chromene-3- carbonitrile (2) and 1,2-diamino-1,4,5,6,7,8-hexahydro-4-(4-methoxyphenyl)-7,7-dimethyl-5-oxo-3-quinolinecarbonitrile (11) which were utilized as starting products for the synthesis of S-nucleoside analogues of kinds 10, 15 and C-nucleoside analogues of types 12, 13 is presented in the current study. The antibacterial and antifungal activities of these new compounds were evaluated. The structures of the new products were confirmed on the basis of elemental and spectral analysis results.

Keywords: Chromeno[2, 3-b]pyridines, [1, 2, 4]triazolo[1, 5-a]quinolines, L-rhamnopyranosyl bromide, antimicrobial activity.

Order Reprints Order Eprints Rights & PermissionsPrintExport

Article Details

VOLUME: 12
ISSUE: 1
Year: 2015
Page: [13 - 20]
Pages: 8
DOI: 10.2174/1570178611666140304000403