Atherogenic Versus Non-atherogenic Lipoprotein Profiles in Healthy Individuals. Is There a Need to Change Our Approach to Diagnosing Dyslipidemia?
S. Oravec, A. Dukat, P. Gavornik, M. Kucera, K. Gruber, L. Gaspar, M. Rizzo, P.P. Toth, D.P. Mikhailidis and M. Banach
Affiliation: Department of Hypertension, Chair of Nephrology and Hypertension, Medical University of Lodz, Zeromskiego 113; 90-549 Lodz, Poland.
Keywords: Atherogenic normolipidemia, lipoprotein profile, low density lipoprotein, small dense LDL, very low-density lipoprotein.
The electrophoretic separation of lipoproteins on polyacrylamide gels enables the quantification of nonatherogenic
and atherogenic plasma lipoproteins including small dense low density lipoprotein (sdLDL) particles, which
represent the atherogenic lipoprotein subpopulations in plasma. This methodology could help distinguish between nonatherogenic
hyperlipidemia, normolipidemia with an atherogenic lipoprotein profile, non-atherogenic normolipidemia,
and atherogenic hyperlipidemia. According to our pilot research of a normolipidemic population, the atherogenic lipoprotein
profile might be present in about 6% of normolipidemic young healthy individuals. Therefore, if confirmed by other
studies, it will be necessary to consider a different diagnostic approach and risk stratification for patients with atherogenic
normolipidemia (as well as non-atherogenic hypercholesterolemia).
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