Current Medicinal Chemistry

Atta-ur-Rahman, FRS
Honorary Life Fellow
Kings College
University of Cambridge


Cholesterol Homeostasis Failure in the Brain: Implications for Synaptic Dysfunction and Cognitive Decline

Author(s): Marco Segatto, Loris Leboffe, Laura Trapani and Valentina Pallottini

Affiliation: Department of Science, University Roma Tre, Viale G. Marconi, 446, I-00146 Roma, Italy.

Keywords: Brain, cholesterol, cognitive decline, memory, neurodegeneration, synapse.


Cholesterol is one of the most important molecules in cell physiology because of its involvement in several biological processes: for instance, it determines both physical and biochemical properties of cell membranes and proteins. Disruption to cholesterol homeostasis leads to coronary heart disease, atherosclerosis and metabolic syndrome. Strong evidence suggests that cholesterol also has a crucial role in the brain as various neurological and neurodegenerative disorders, including Alzheimer’s, Huntington’s and Parkinson diseases are associated with disruptions to cholesterol homeostasis. Here, we summarize the current knowledge about the role cholesterol plays at synaptic junctions and the pathological consequences caused by disruptions in the homeostatic maintenance of this compound.

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Article Details

Page: [2788 - 2802]
Pages: 15
DOI: 10.2174/0929867321666140303142902