Current Immunology Reviews

Cecil Czerkinsky  
Institut de Pharmacologie Moleculaire et Cellulaire
660 Route des Lucioles
Valbonne, 06560


The Neutrophil: An Underappreciated But Key Player in SLE Pathogenesis

Author(s): Neelakshi R. Jog, Roberto Caricchio and Philip L. Cohen

Affiliation: Neelakshi R. Jog, Rheumatology Section, Department of Medicine, Temple University School of Medicine, 1182A MERB, 3500 N. Broad Street, Philadelphia, PA 19140, USA.


Systemic lupus erythematosus (SLE) is a complex multi-organ autoimmune disease, the pathogenesis of which is still not deciphered. The neutrophil, an innate immune cell critical in controlling infections, has traditionally not been regarded as a contributor to systemic autoimmunity due to its lack of specificity and short lifespan. Many recent findings have instead shown that these cells have a role in regulating the adaptive as well as the innate immune response, and that they may play a key role in the abnormal responses seen in SLE. Neutrophils can secrete various cytokines and cellular mediators that can regulate both innate and adaptive arms of immunity, and may serve as a source of immunogens that may trigger and reinforce autoimmunity. In the present review we will discuss the relevance of neutrophil functions and neutrophil regulation of the immune response in the context of SLE.

Keywords: Innate immunity, lupus, neutrophil.

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Article Details

Page: [222 - 230]
Pages: 9
DOI: 10.2174/1573395510666140301005421