Recent Trends in Chiral Separations by Nano Liquid Chromatography and Nano Capillary Electrophoresis
Imran Ali, Zeid A. Al-Othman, Abdulrahman Al-Warthan and Hassan Y. Aboul-Enein
Affiliation: Department of Chemistry, Jamia Millia Islamia (Central University), New Delhi-110025, India.
Keywords: Chiral separations, nano liquid chromatography (NLC), nano capillary electrophoresis (NCE), chiral recognition
mechanisms, Challenges and prospectives.
Chiral separation at nano scale is gaining importance in drugs development, proteomic, genomic and environmental
sciences. Generally, traces of drugs are found in our body for several weeks. These cannot be detected by conventional
analytical techniques. The present article discusses the advances in chiral resolution at nano scale using nano liquid
chromatography (NLC) and nano capillary electrophoresis (NCE). The instrumentation, chiral selectors, mechanisms of
chiral recognition and future challenges and prospectives have been discussed.
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