Association of Serum Uric Acid and Metabolic Syndrome in Type 2 Diabetes
Shokoufeh Bonakdaran and Banafsheh Kharaqani
Affiliation: Endocrine Research Center, Ghaem Hospital, Ahmadabad Street, Mashhad, Iran.
Keywords: Diabetes, hypertension, insulin resistance, metabolic syndrome, uric acid.
Aim: The relationship between elevated serum uric acid level and metabolic syndrome (MS) has been debated. There is
no data concerning this relation in Iranian population-based studies. The aim of this study was to determine the prevalence
of hyperuricamia and its association with MS in type 2 diabetes mellitus (DM).
Patients and Methods: This was a cross- sectional study in 1978 diabetic patients. Hyperuricamia was defined as uric
acid ≥ 7 and ≥ 5.5 mg/dl for men and women respectively. Diagnosis of metabolic syndrome was based on ATPIII criteria.
Clinical and biochemical parameters in hyperuricaemic and normouricaemic patients compared with other.
Results: The prevalence of hyperuricaemia and metabolic syndrome was 12.7% and 65.5% respectively. The prevalence
of MS significantly increased in the highest quartile of uric acid levels compared with lowest quartile (74.4% vs 55.9%,
p<0.001). Serum uric acid had positive association with cholesterol, triglyceride, non-HDL cholesterol and a negative association
with fasting blood sugar (FBS), glycosylated hemoglobin (HbA1C) and HDL cholesterol. Possible independent
biochemical predictors of hyperuricamia were cholesterol, triglyceride, creatnine and FBS.
Conclusion: The prevalence of MS and its components increases with increasing levels of uric acid in type 2 diabetes.
Regular assessment of uric acid could give information for predicting of MS and prevention of atherosclerosis in type 2
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