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Current Diabetes Reviews
ISSN (Print): 1573-3998
ISSN (Online): 1875-6417
VOLUME: 10
ISSUE: 2
DOI: 10.2174/1573399810666140228160938      Price:  $58









Association of Serum Uric Acid and Metabolic Syndrome in Type 2 Diabetes

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Author(s): Shokoufeh Bonakdaran and Banafsheh Kharaqani
Pages 113-117 (5)
Abstract:
Aim: The relationship between elevated serum uric acid level and metabolic syndrome (MS) has been debated. There is no data concerning this relation in Iranian population-based studies. The aim of this study was to determine the prevalence of hyperuricamia and its association with MS in type 2 diabetes mellitus (DM).

Patients and Methods: This was a cross- sectional study in 1978 diabetic patients. Hyperuricamia was defined as uric acid ≥ 7 and ≥ 5.5 mg/dl for men and women respectively. Diagnosis of metabolic syndrome was based on ATPIII criteria. Clinical and biochemical parameters in hyperuricaemic and normouricaemic patients compared with other.

Results: The prevalence of hyperuricaemia and metabolic syndrome was 12.7% and 65.5% respectively. The prevalence of MS significantly increased in the highest quartile of uric acid levels compared with lowest quartile (74.4% vs 55.9%, p<0.001). Serum uric acid had positive association with cholesterol, triglyceride, non-HDL cholesterol and a negative association with fasting blood sugar (FBS), glycosylated hemoglobin (HbA1C) and HDL cholesterol. Possible independent biochemical predictors of hyperuricamia were cholesterol, triglyceride, creatnine and FBS.

Conclusion: The prevalence of MS and its components increases with increasing levels of uric acid in type 2 diabetes. Regular assessment of uric acid could give information for predicting of MS and prevention of atherosclerosis in type 2 diabetes.

Keywords:
Diabetes, hypertension, insulin resistance, metabolic syndrome, uric acid.
Affiliation:
Endocrine Research Center, Ghaem Hospital, Ahmadabad Street, Mashhad, Iran.