Title:Ca<sup>2+</sup>/Calmodulin-Dependent Protein Kinase- II in Vasoactive Peptide- Induced Responses and Vascular Biology
VOLUME: 12 ISSUE: 2
Author(s):Estelle R. Simo Cheyou, Ali Bouallegue and Ashok K. Srivastava
Affiliation:CRCHUM- 900 St Denis Street, Montreal, (Quebec), Canada, H2X 0A9.
Keywords:Angiotensin-II, CaMKII, endothelin-1, G-protein-coupled receptor, hypertrophy, migration, proliferation, VSMC.
Abstract:Vasoactive peptides such as angiotensin II and endothelin-1 as well as growth factors regulate vascular homeostasis
through signaling pathways that are triggered in both normal and disease states. These vasoactive peptides and
growth factors also increase the cellular levels of calcium which, through calcium binding effector systems initiating the
downstream signaling and physiological responses in target cells. A multifunctional calcium-calmodulin-dependent protein
kinase II (CaMKII) has emerged as an important transducer of vasoactive peptide-induced responses in vascular
smooth muscle cells (VSMC). The catalytic activity of CaMKII can be stimulated by autophosphorylation and oxidation
leading to the activation of signaling events that mediate growth, proliferation, migration, and gene transcription in
VSMC. Pharmacological and gene deletion approaches have demonstrated a requirement of CaMKII in mediating the mitogen-
activated protein kinase and phosphatidyl-inositol 3-kinase/protein kinase B signalling, as well as the proliferative,
migratory and transcriptional responses of vasoactive peptides. In addition, a potential involvement of hyperactive CaMKII
in animal models of vascular disease has also been reported. Therefore, this review aims to highlight the role of
CaMKII in mediating signaling and physiological responses in VSMC and discuss its potential role in vascular pathophysiology.
