Wave Intensity Analysis in the Human Coronary Circulation in Health and Disease
Sayan Sen, Ricardo Petraco, Jamil Mayet and Justin Davies
Affiliation: International Centre of Circulatory Health, National Heart and Lung Institute, 59-61 North Wharf Road, London, W2 1LA, UK.
Keywords: Collaterals, iFR, wave intensity.
Coronary artery hemodynamics are very different to that of the systemic arteries; unlike the systemic circulation,
in the coronary circulation pressure is generated from both the proximal and distal end of the artery – due to the effect
of contraction and relaxation of the myocardium on the microvasculature. As a result, the systemic artery hemodynamic
model cannot be used to explain the pressure-flow relationship in the coronaries. Wave intensity analysis is an investigative
tool that is able to distinguish simultaneous proximal and distal influences on coronary blood flow and is
therefore uniquely suitable for the study of coronary haemodynamics. This review discusses the concept behind waveintensity
analysis and evaluates how it has been used to characterise and provide new insights on coronary haemodynamics
in health and disease.
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