Effect of HPMC - E15 LV premium Polymer on Release Profile and Compression Characteristics of Chitosan/ Pectin Colon Targeted Mesalamine Matrix Tablets and in vitro Study on Effect of pH Impact on the Drug Release Profile
A.M.J. Newton and Prabakaran Lakshmanan
Affiliation: Jawaharlal Nehru Technological University, Hyderabad, Andhra Pradesh. R.R College of pharmacy, No. 67, Rajareddy layout, Chikkanbanavara, Banglore-560 090, India.
Keywords: Chitosan, compression characteristics, colonic delivery, HPMCE15LV, IBD, pectin.
The study was designed to investigate the in vitro dissolution profile and compression characteristics of colon
targeted matrix tablets prepared with HPMC E15 LV in combination with pectin and Chitosan. The matrix tablets were
subjected to two dissolution models in various simulated fluids such as pH 1.2, 6, 6.8, 7.2, 5.5. The fluctuations in colonic
pH conditions during IBD (inflammatory bowel disease) and the nature of less fluid content in the colon may limit the expected
drug release in the polysaccharide-based matrices when used alone. The Hydrophilic hydroxyl propyl methylcellulose
ether premium polymer (HPMC E15 LV) of low viscosity grade was used in the formulation design, which made an
excellent modification in physical and compression characteristics of the granules. The release studies indicated that the
prepared matrices could control the drug release until the dosage form reaches the colon and the addition HPMC E15 LV
showed the desirable changes in the dissolution profile by its hydrophilic nature since the colon is known for its less fluid
content. The hydrophilic HPMC E15 LV allowed the colonic fluids to enter into the matrix and confirmed the drug release
at the target site from a poorly water soluble polymer such as Chitosan and also from water soluble Pectin. The dramatic
changes occurred in the drug release profile and physicochemical characteristics of the Pectin, Chitosan matrix tablets
when a premium polymer HPMC E15 LV added in the formulation design in the optimized concentration. Various drug
release mechanisms used for the examination of drug release characteristics. Drug release followed the combined mechanism
of diffusion, erosion, swelling and polymer entanglement. In recent decade, IBD attracts many patents in novel
treatment methods by using novel drug delivery systems.
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