Betulinic Acid as a Potent and Complex Antitumor Phytochemical: A Minireview
Dorina Gheorgheosu, Oana Duicu, Cristina Dehelean, Codruta Soica and Danina Muntean
Affiliation: Department of Pharmaceutical Chemistry, "Victor Babes" University of Medicine and Pharmacy, 2, Eftimie Murgu Sq., 300041, Timisoara, Romania.
Betulinic acid (BA), a natural compound with a lupan skeleton, has been highly investigated in the past decade for a plethora
of beneficial properties, including anti-cancer, anti-inflammatory, anti-angiogenic, immune-modulatory, and anti-HIV effects. In
particular, BA has been reported to be effective in vitro against tumor cell lines of different origins, and also in vivo, in animal models of
cancer. The best characterized mechanism of its antitumor effect consists of triggering apoptosis via the mitochondrial pathway. BA has
also an anti-metastatic effect via the prevention of the epithelial-to-mesencymal transition in highly aggressive melanoma cells.
Furthermore, in the same model, BA is able to counteract the pro-invasive potential of the pro-tumoral protein neutrophil gelatinaseassociated
lipocalin. The present review addresses the current state of knowledge regarding the anti-tumor effects of betulinic acid, a
potent chemotherapeutic agent.
Keywords: Angiogenesis, anti-tumor, betulinic acid, melanoma, mitochondria.
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