Current Microwave Chemistry

Bimal K. Banik
Vice President of Research & Education Development
Community Health Systems of South Texas (CHSST)
Edinburg, TX
USA

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A Rapid Protocol for the Synthesis of N-[2-(alkyl/aryl)-4-phenyl-1Himidazol- 1-yl] benzamides via Microwave Technique

Author(s): Fatih Yılmaz and Emre Mentese

Affiliation: Department of Chemistry, Recep Tayyip Erdogan University, 53100, Rize, Turkey.

Keywords: Acetamidrazone, amide hydrazone, benzamide, benzhydrazide, catalyst-free, hydrazide imide, imidazole, iminoester hydrochloride, green chemistry, microwave irradiation, phenylacyl bromide.

Graphical Abstract:


Abstract:

Benzohydrazides (2a-g) were synthesized starting from iminoester hydrochlorides and benzhydrazide. The treatment of compounds 2a-g with phenylacyl bromide derivatives gave N-[2-(alkyl/aryl)-4-phenyl-1H-imidazol-1-yl] benzamides. The synthetic protocol was performed under microwave irradiation and the lowest quantity of the solvent was used to obtain the best green protocol. This method has been found to be more efficient than others in terms of green chemistry.

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Article Details

VOLUME: 1
ISSUE: 1
Page: [47 - 51]
Pages: 5
DOI: 10.2174/2213335601999140221111915