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Current Microwave Chemistry
ISSN (Print): 2213-3356
ISSN (Online): 2213-3364
VOLUME: 1
ISSUE: 1
DOI: 10.2174/2213335601999140221111915









A Rapid Protocol for the Synthesis of N-[2-(alkyl/aryl)-4-phenyl-1Himidazol- 1-yl] benzamides via Microwave Technique

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Author(s): Fatih Yılmaz and Emre Mentese
Pages 47-51 (5)
Abstract:
Benzohydrazides (2a-g) were synthesized starting from iminoester hydrochlorides and benzhydrazide. The treatment of compounds 2a-g with phenylacyl bromide derivatives gave N-[2-(alkyl/aryl)-4-phenyl-1H-imidazol-1-yl] benzamides. The synthetic protocol was performed under microwave irradiation and the lowest quantity of the solvent was used to obtain the best green protocol. This method has been found to be more efficient than others in terms of green chemistry.
Graphical Abstract:
Keywords:
Acetamidrazone, amide hydrazone, benzamide, benzhydrazide, catalyst-free, hydrazide imide, imidazole, iminoester hydrochloride, green chemistry, microwave irradiation, phenylacyl bromide.
Affiliation:
Department of Chemistry, Recep Tayyip Erdogan University, 53100, Rize, Turkey.