Synthesis and Bioactivity of Novel Carvacrol and Thymol Derivatives Containing 5-Phenyl-2-furan
A series of novel carvacrol and thymol derivatives containing 5-phenyl-2-furan were synthesized. The antitumor
tests showed that the title compounds exhibited promising activity against Bel-7402 and KB. The fungicidal tests
showed that most of the title compounds had a considerable effect on the selected fungi. Generally the bioactivity of the
carvacrol and its derivatives were better than that of the thymol and its derivatives. The substituted groups on the orthoand
para- positions gave better activity than that of ones on the meta-position.
Keywords: Synthesis, 5-Phenyl-2-furan, Carvacrol and thymol derivatives, Antitumor activity, Antifungal activity.
Rights & PermissionsPrintExport