-gingerol as a Cancer Chemopreventive Agent: A Review of Its Activity on Different Steps of the Metastatic Process
Juliana Poltronieri, Amanda B. Becceneri, Angelina M. Fuzer, Julio Cesar C. Filho, Ana Carolina B.M. Martin, Paulo Cezar Vieira, Normand Pouliot and Márcia R. Cominetti
Affiliation: Departamento de Gerontologia, Universidade Federal de São Carlos, Rodovia Washington Luís, Km 235, São Carlos, SP, 13565-905, Brazil.
Keywords: Apoptosis, cancer, ginger, 6-gingerol, metastasis, natural product.
For many years, ginger or ginger root, the rhizome of the plant Zingiber officinale, has been consumed as a
delicacy, medicine, or spice. Several studies have been conducted on the medicinal properties of ginger against various
disorders, including cancer. Cancer is the second leading cause of death, and chemoprevention is defined as the use of
natural or synthetic substances to prevent cancer initiation or progression. Evidence that ginger-derived compounds have
inhibitory effects on various cancer cell types is increasingly being reported in the scientific literature. In this review we
focused on the cancer chemopreventive effects of -gingerol, the major pungent component of ginger, and its impact on
different steps of the metastatic process.
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